Thyroid hormones and natriuretic peptide predict long-term outcomes after acute coronary events

BMC CDNew publication by Lithuanian Biological Psychiatry Association members in BMC Cardiovascular Disorders (Impact factor 1.88) analyses thyroid hormones (i.e., fT4 level and fT3/fT4 ratio) and N-terminal pro-B-Type natriuretic peptide level as predictors of long-term outcomes of coronary artery disease patients.

Altered thyroid function and increased rates of N-terminal pro-B-Type natriuretic peptide (NT-pro-BNP) are highly prevalent in coronary artery disease patients with heart failure, and are associated with unfavorable prognosis. This study was undertaken to examine the relationship and prognostic impact of thyroid hormones, inflammatory biomarkers, and NT-pro-BNP on long-term outcomes in patients after acute coronary syndrome. Analyses provided significant prognostic information with the highest risk for all-cause mortality in the low cut off measures of fT3/fT4 ratio <0.206 and NT-pro-BNP ≥290.4 ng/L and fT4 level >12.54 pg/ml.

Study findings suggest that fT4 level and fT3/fT4 ratio together with NT-pro-BNP, are valuable and simple predictors for the identification of CAD patients that are more likely to experience negative long-term outcomes after cardiac rehabilitation.